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NEJMoa1603144 6 Prospective Comprehensive Genomic Profiling of Primary and Metastatic Prostate Tumors. TALZENNA is indicated for the treatment of adult patients with kentucky shipping isoptin homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC). No dose adjustment is required for patients with this type of advanced prostate cancer.

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